This process is also crucial for modulating both strength and content of an existing memory and forms a promising therapeutic target for fear-related disorders.
However, the molecular and cellular mechanism of adaptive reconsolidation still remains obscure.
Here we show that retrieval of fear memory induces a biphasic temporal change in Glu A2-containing AMPA-type glutamate receptor (AMPAR) membrane expression and synaptic strength in the mouse dorsal hippocampus.
Blockade of retrieval-induced, regulated, Glu A2-dependent endocytosis enhanced subsequent expression of fear.
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The school system is the result of a consolidation of three school districts.In the meantime, to ensure continued support, we are displaying the site without styles and Java Script.Upon retrieval, fear memories are rendered labile and prone to modification, necessitating a restabilization process of reconsolidation to persist further.Riverdale was previously a co-founding member of the North Central Conference from 1962 until joining the BVC in 2014.Riverdale was originally part of a group of ten schools that were going to form the Northern 10 Athletic Conference (N10) in 2014-15, ultimately causing the dissolution of the North Central Conference.
In addition, this blockade prevented the loss of fear response after reconsolidation-update of fear memory content in the long-term.